|
Symbol Name ID |
Map3k14
mitogen-activated protein kinase kinase kinase 14 MGI:1858204 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Mouse Phenotypes | immune system phenotype |
decreased B cell proliferation |
abnormal thymus morphology |
abnormal thymus cell ratio |
abnormal thymus corticomedullary boundary morphology |
absent thymus corticomedullary boundary |
abnormal thymus medulla morphology |
small thymus |
thymus cyst |
lacrimal gland inflammation |
pancreas inflammation |
enlarged spleen |
abnormal lymphopoiesis |
abnormal class switch recombination |
decreased transitional stage T1 B cell number |
decreased transitional stage T2 B cell number |
arrested B cell differentiation |
increased eosinophil cell number |
decreased mast cell number |
decreased dendritic cell number |
decreased germinal center B cell number |
decreased B-1 B cell number |
decreased B-2 B cell number |
decreased follicular B cell number |
decreased marginal zone B cell number |
increased mature B cell number |
increased marginal zone B cell number |
decreased B cell number |
decreased NK T cell number |
decreased regulatory T cell number |
abnormal lymphocyte morphology |
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology |
abnormal NK T cell morphology |
abnormal spleen morphology |
abnormal spleen B cell follicle morphology |
decreased spleen B cell follicle number |
abnormal spleen primary B follicle morphology |
abnormal spleen marginal zone morphology |
absent spleen marginal zone |
abnormal B cell physiology |
abnormal B cell activation |
abnormal immunoglobulin level |
decreased IgA level |
decreased IgE level |
decreased IgG1 level |
decreased IgG2b level |
decreased IgG level |
decreased IgM level |
decreased immunoglobulin level |
abnormal T cell activation |
decreased circulating interferon-gamma level |
decreased circulating interleukin-4 level |
abnormal immune system morphology |
absent follicular dendritic cells |
abnormal Peyer's patch morphology |
decreased Peyer's patch number |
absent Peyer's patches |
absent mesenteric lymph nodes |
enlarged lymph nodes |
small axillary lymph nodes |
small brachial lymph nodes |
absent axillary lymph nodes |
absent cervical lymph nodes |
absent inguinal lymph nodes |
absent popliteal lymph nodes |
absent lymph nodes |
abnormal immune system physiology |
abnormal dendritic cell physiology |
abnormal dendritic cell antigen presentation |
increased inflammatory response |
bile duct inflammation |
liver inflammation |
kidney inflammation |
lung inflammation |
increased susceptibility to parasitic infection |
increased susceptibility to infection |
increased length of allograft survival |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Map3k14aly/Map3k14aly | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Map3k14m1Btlr/Map3k14m1Btlr | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Map3k14tm1.2Gne/Map3k14tm1.2Gne | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Map3k14tm1Rds/Map3k14tm1Rds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cd19tm1(cre)Cgn/Cd19+ Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky (conditional) |
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| Cd19tm1(cre)Cgn/Cd19+ Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky (conditional) |
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| Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ Map3k14tm1.1Gne/Map3k14tm1.1Gne (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Map3k14tm1.1Gne/Map3k14tm1.1Gne Cd19tm1(cre)Cgn/Cd19+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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